Participant 1: UNI WUERZBURG
University of Würzburg, Department of Toxicology, Würzburg, Germany (www.uni-wuerzburg.de)
Participant leader: Prof. Dr. Wolfgang Dekant
Relevant expierience and laboratory resources
The Institute of Toxicology in Würzburg has a track record of internationally acclaimed research on the biotransformation of xenobiotics and studies related to interactions of biologically reactive intermediates with cellular macromolecules and function. Part of this is based on the application of in vitro models (freshly isolated cell preparations, cell culture, subcellular fractions and isolated perfused organs) to study mechanisms of toxicity. The laboratory is/was funded by the European Union, the Deutsche Forschungsgemeinschaft, the Bundesministerium für Forschung und Technologie, the Umweltbundesamt, the US EPA, the US HEI, industry and a number of foundations. The equipment is at the cutting edge of technology and includes gas chromatography-mass spectrometry with different ionisation techniques, liquid chromatography coupled to a tandem mass spectrometer (MS-MS) with electrospray and atmospheric pressure chemical ionisation interfaces, liquid chromatography coupled to a linear ion trap mass spectrometer, high performance liquid chromatography with fluorescence, diode array and UV-detectors, and a full array of molecular and cell biology techniques. Chemical and radiochemical synthesis and a 600 MHz (1H)nuclear magnetic resonance spectrometer is available on the campus. The laboratory has also obtained relevant experience in the application of NMR-techniques to characterize changes in the composition of body fluids induced by toxicants (Metabonomics), planning and evaluation of animal toxicity studies (dedicated animal facilities in the department with experienced staff), and project management.
Principal staff involved:
Prof. Dr. Wolfgang Dekant was a member of the Scientific Committee on Toxicity, Ecology and the Environment (CSTEE) of the European Union, he presently is member of the Scientific Committee on Health and Environmental Risks (SCHER) and of the Food Additives Panel of EFSA. He also is Editor of Toxicology Letters, associate editor of Toxicology and Applied Pharmacology and is/was member of the editorial board of Chemical Research in Toxicology, Toxicological Sciences, and Xenobiotica. In this capacity and in activities for national and international organisations such as the WHO (ICPS, JECFA) or the US EPA, he regularly peer reviews publications and other scientific work.
Dr. Angela Mally, an European Registered Toxicologist with a strong background in mechanistic toxicology and chemical carcinogenesis, has already participated in a number of scientific projects as Principal Investigator and coordinates the experimental work performed at the University of Würzburg.
Dr. Ute Schauer is responsible for conducting the experimental work by Participant 1, assisted by Carolin Hamberger and Sabrina Moro as part of their PhD thesis on mechanism of furan toxicity related to DNA and protein binding.
Dipl. Ing (FH) Hannelore Popa-Henning, with significant experience in management of scientific projects funded by the EU (FP5 and FP6, INCO), national and international organisations is responsible for project management as assistant to the coordinating institution.