Deutsch Intern

     

    Work-package
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    Workpackage title

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    Top. 1

    Covalent binding of furan to DNA?

    1.1

    Characterisation of DNA-damage and covalent binding of furan with Accelerator mass spectrometry

    P1

    1.2

    Aspects of biotransformation

    P1

    Top. 2

    Mode of action and biomarkers of furan toxicity in rats

    2.1

    Repeat dose administration of furan to rats as a central source for biomarker analysis

    P1

    2.2

    Characterization of liver responses to furan

    P3

    Top. 3

    Gentoxic effects of furan in vivo in rodents

    3.1

    In vivo clastogenic effects of furan and its key metabolite cis-2-butene-1,4-dial in rats exposed to acute and sub-acute doses

    P5

    3.2

    Assessment of in vivo genotoxicity of furan in the mouse

    P2

    Top. 4

    Role of oxidative DNA damage in the mechanism of neoplastic transformation

    4

    Evaluation of the role of oxidative DNA damage in the etiology of liver toxicity and genotoxicity induced by repeated administrations of furan

    P2

    Top. 5

    Markers of non-genotoxic mechanisms

    5

    Markers of non-genotoxic mechanisms

    P4

    Top. 6

    Molecular mechanisms of mutagenesis in mammalian cells

    6.1

    Mechanism of mutagenesis of furan in mammalian cells in culture

    P2

    6.2

    In vitro cytogenetic profile of furan and its key metabolite cis-2-butene-1,4-dial in human lymphocytes and rodent cell lines

    P5

    6.3

    Cytogenetic analysis in vitro in rodent cell lines to study the influence of DNA repair of different DNA lesions and adducts

    P5

    Top. 7

    In vitro toxicity of furan and its metabolites

    7

    In vitro toxicity of furan and its metabolites

    P3

    Top. 8

    Analysis of furan in food and mechanisms of formation during food processing

    8.1

    Food analysis as a better basis for exposure assessment from food

    P6

    8.2

    Mechanisms of formation of furan during food processing

    P8

    Top. 9

    Risk assessment of furan

    9

    Risk assessment of furan

    P1

    Top. 10

    Management, dissemination and communication of results

    10

    Management, dissemination and communication of results

    P1

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    Universität Würzburg
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    97070 Würzburg

    Phone: +49 931 31-0
    Fax: +49 931 31-82600

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    Sanderring Röntgenring Hubland Nord Hubland Süd Campus Medizin